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KMID : 0366220080430020122
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Korean Journal of Hematology
2008 Volume.43 No. 2 p.122 ~ p.124
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Reverse Seroconversion of Hepatitis B following Allogenic Hematopoietic Stem Cell Transplantation from a Hepatitis Immune Donor in a Multiple Myeloma Patient
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Kwon Bo-Ran
Mok Jeong-Ha
Bae Jung-Ho
Seol Hee-Yun
Sol Young-Mi
Song Moo-Kon
Choi Young-Jin
Shin Ho-Jin
Chung Joo-Seop
Cho Goon-Jae
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Abstract
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A 52-yr-old male with multiple myeloma underwent autologous stem cell transplantation in June 2002. In August 2004, the multiple myeloma had recurred. The patient received allogenic stem cell transplantation in September 2005. Before undergoing transplantation, the presence of HBsAb and the absence of HBsAg were noted. The patient underwent allogenic peripheral blood stem cell transplantation (PBSCT) from a sibling donor who was hepatitis surface antibody (HBsAb) positive and hepatitis surface antigen (HBsAg) negative. Nineteen months after the PBSCT, the liver function tests showed elevation of the aminotransferases. The patient was HBsAg positive and HBsAb negative. The liver iopsy specimen revealed hepatitis. The reactivation of a hepatitis B virus infection, in a hepatitisB immune patient, referred to as reverse seroconversion, is a rare complication of hematopoietic stem cell transplantation.
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KEYWORD
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Hepatitis B virus, Seroconversion, Multiple myeloma, Stem cell transplantation
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